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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52b2018e75aaa3a60260ed223397773d6a8bd3407fdaa7681fa5d6dae0a5d0d9' 
  AND token = 'XHKLwjZ5byG9P3S+wv2xNOEV3KQuq7CQ10uIMJy2UqU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}