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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8566ff6c0252ec9551d7bba06a5a542f2da666e0491fea0ac6d9352aa33bd6ce' 
  AND token = 'O/n+nCMDnzKsmc6XMzQvNR8QTGROWHWr/e0RaYOL4zs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}