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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22f1ce5d0fd009d0d852c3958511223aba945508f5d17e223c3c9db1c88f2e5f' 
  AND token = 'QBfNAxe0y32ZMqylJ1ytwtvjKBcEsFSY02qHpsfuMhc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}