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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '485e7e1e816b266362cf7e253ec8c43421c1da767e28c86e66a9e5ebc6d41aff' 
  AND token = 'o7XceJaex5k+Z1uALb3lCp1ZrL4BOqYiv++uLYxOXLY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}