SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '442abea8771ae3332d1196daf4bfc1d5b15855725aeaf40672308989347a0fce' 
  AND token = 'GqOQ1Wk8HD7P6aJc93WB6t++XBA675qeRdAHPAkOMCA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}