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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e188762cb1c6db3c8820e0f172b8e8cfad7057051176210c6a766aa71446a485' 
  AND token = 'ym8+htyNLIqJeEhPnDCoF2GLg+xJbs1umDUsmRlZyCw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}