SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2c81ac7752669aac7397a67623dab90bd264069f4863d200032625c23c935df4' 
  AND token = 'nxzUq0hhPEOj3KGk05Edm/VnIr78801INaat9nVowbg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}