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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49049c5afbe5fb9b71ebb13df067edefcc317c451e69ad123dc80b575ca44df4' 
  AND token = 'EdLSj8D4ojQxT3JPrpUaUdOAD+vXgiDtD37rSf2hnGU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00050

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}