SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22185c9c3ef49d0f231132fab96cba1bfa53cee1e34aec591c1082b457a3a43d' 
  AND token = 'IT11zbMRMj+OuYdWCwTybkXokRdTFv1tSLtPvD1GNm0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}