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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af0b7b2278de4cee4daab9bd11b5d96c436237bb93dffc0c92042238a7332160' 
  AND token = 'c1wgyXA4TlhiyR84Gt+N5uhbTkoUUFLZ37h/ZmTfPKk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00013

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}