SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e290625df4321327604434b79c4c1011c907e2c58bf119c5f87a592228c9848' 
  AND token = 'Gmkjx2EGVNRcr/XDKvxZaU0cZEG0aAThRJZ7gPyzyN4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}