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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3833554ccca12f70a804f57b36f12a64424bc2a5d3258fd5f122ddff57723454' 
  AND token = 'v6NzpjdsU72pMMLx/0X1ON+UkIPtNvX+NZ1kiKZqlTw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}