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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4edbc3ab4604d061c1a36d93934442c77108714a1a9f9d04908a0efbdea83cc5' 
  AND token = 'ztA3OFrBK+3ttKFQK32bRRB0KTjVSL7jVi5pxNEOZW4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}