SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c16d6a59ea190f26ca4da5fce393a47297503cfba7c71ff5feee84bdffda14f8' 
  AND token = 's2IH0x29GJs7/CetpUgqz2FoS0YUibdA3qssV8qyfNM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}