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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a646b446e57321acfa3e210d6e6a68b90ec74577843583fd944f46f7fffd2458' 
  AND token = 'e2tkFDF6DsvRoS7z7ix5ur0Knwh0I3Uov3LdR9nE4P0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00246

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}