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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43e2756a0326078084745a5b3d3b969c164facf8cf93d2263816d53455a20740' 
  AND token = '4iYsmKIJw9r3LkwazRoK2SOLzHYzR6oZacTBfnXAGus=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}