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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48ad3a4e4bb805b12e2f026b0a364125c6aeb422fd37d450ad549f26616b9f45' 
  AND token = 'iVSN7UgIGVEdTRz4FVY3rGcMdSSBp4O2v+iopUniYZg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}