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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd78ca0839d608919d6f834d73ad1aa61b83a6de462c668a9e8e72d110554dab0' 
  AND token = 'vRx3ez6zafPHUNe319BzeQBLt60aWvfTuXkGp66A4Yk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}