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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2246c7eef079ed4e869bc41a2ac02a0a8e6faba57e3b41b668aae170484a773c' 
  AND token = '4u4ZjPzBtYPhcTkoCLF9CP1XCkVwcW6L2eRraPDkZLg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}