SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd45e09e5018632f5c125128c1c755489ec00424fa05a00ff91d6156aa6af8486' 
  AND token = 'Qo4ryCC1gS5AFF7LxrwRboAzav3jr4OVTwcKq4FQxoc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}