SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '245e73572a8e7d1ca8033056a5366e0a0bffb8a4f69d51fb5e010d945c3091e8' 
  AND token = 'nPZKwOwUy/VVbFALCW8VCQYMemwr3pZOPS/mF95bhY0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}