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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '844a9bcbabb82f9c7811d05c857dc603cf7a648d8ef53005fb00adfb941d7649' 
  AND token = 'CwlXe9dN4a9vxF6G43cpPMaB7ijWRjqk9bqUtSsTGcU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}