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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2efccf9af934d82b2b8090fd5179d40a64142331f80a8e88a6ab161a521da494' 
  AND token = '3nbVhmDYdsuYs0hN7BKtWSPvyFq7MfQHcnVeOHQtwDg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}