SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21b7217a80a9dba52f8a902ebcc07cd8efe03d243d6082397bc204669a4f0125' 
  AND token = 'VRMw32T9b/QCvaK9H7pIuNQRwxkGyiNzV1P9iwO3qBs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}