SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4486f1a6abae480e249d224ba511d7cda0afcab4d7ef157fc1eaa9bda6d63d22' 
  AND token = 'O25qP5RV3DEtBioqqu3Rh/o6FkJdxITcAUc66Pgbmcc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}