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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12b9d76173a22fca7b5ab44ecb775a0a2d7f12a0b34a8a4d1da5aa5d5f506982' 
  AND token = 'DzScLRiW+nsKN+tV5OmEZatqyD48yvPl3wVbacf4kcE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}