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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49da00b1dde0531ef0998678280994d531ac0bfa05d68c1b52263e3e87a8a816' 
  AND token = '5E/EZw+0GjKcC974MyrMFcRjzk7cnJ/ytNoZl5nsqbY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}