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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49da112dfad91c3dfb15acfd4171dee2eb0489f53ab15b59384f8aef068b9e22' 
  AND token = '51GPOCRAnnrliOZTE7iri7o2yL0TW4WFXLd9oxv8/oc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}