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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46843258a8e7a3aeb6d1082c524f12ea21ba342df17ee1471aa2a86f344ace1f' 
  AND token = 'z4Q0ByIR6Ie8xIA3Ym4khCY6G4WGQO1V59WXmXgr830=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}