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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42321918feaf05b5ae9ec0a207d58c0d15cd5ebf584642cf041fc9f3ac1d2894' 
  AND token = 'wIlcuTgKpynMIBh8rQp52nj708DRZNQrtGmYvDCapcs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}