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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6da12c5250df5d3e83604c209792fe966f6e28bb818cdd47da80d07389f4a600' 
  AND token = 'eT875pRuV4y00ZdIvkEPH036thwyT2z+aTAcgwh1/9A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}