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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '306e458033fa9e588bb76c599bd73fb77f4053c47c7c7dbeb74f0de5f53294b9' 
  AND token = 'uRLsA6Hp3RCq4MxLiY2vwwgoPE+15XMzQR5yIaH0sdY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}