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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '365e220be626753b1694ad1a0604f612f7eccc7636a0dbf925d3b556145f62be' 
  AND token = 'eOt0I6NHXToK+GTAyrVAjqWiTRnxohqq8jvvo1mlD/E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}