SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e5d721ab459f15f3203d6071d2713d139a9e787b12f2bd0be44e174dadb1d6d4' 
  AND token = 'ygh34xWAb2kd3e9OD+Swbla9qrV+VQhGUyQJzOhPWrE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}