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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b495c84af04c31ed2ee6aea9c81c6bb22b13a7bd96ceb22f42c18c169e6f4d12' 
  AND token = 'OvnRxDCmeYLV42H0lxLERZ83eokWR+TwDkyUeQkAt9Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}