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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '346b1b842da491f94c14613af569888141a197089019f9a0aa7836c2e1b38766' 
  AND token = 'r9BoG9YYrJfaa19abluY8x1M73hhbo42W58qccl3G10=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}