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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e801de764ddae4192216cea0664988a1224f124d574c79349724dc572d15e637' 
  AND token = 'ANuWnM3cWXFOYHf0IiIsWP+FSdaQjN4HXz65l0IkUDc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}