SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e746d01edb2fba8c24d26018123abc627181692b2f0404cddcf5a736e087d37' 
  AND token = 'bKWjFSvNr8qGAZ3s/rpmcViYkWUySWTBiqM0Tpiscmc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}