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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b0764c3060daa3f926bf826a5f67994079daed117cea1dd4c7e2779d6e544fe' 
  AND token = '42y4vw7Y2iTmmEXpMelkTZglpkSYqqaSVnhwqOTBgbI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}