SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '683f5aeb0d0180a1c8ce9bbed04757e05b146cfcd6b170c764344b10550c8aaa' 
  AND token = 'cz6PnpV2zz39PvVmG8lk1nL0ekLcBNgq+Lobc1MYrOo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}