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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '048d2cbefa049605149ce01bb5d7bac5701a9dcf5ac772d9323c330df11a579c' 
  AND token = 'K+uKfsFlgMjtTddBU0bARfoPuUdfA8oRmj6ZWOKSSgw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}