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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b8bd50e04b8cc51886e218bf872a5ce0d79c172c1668b70e348a695540e80a0f' 
  AND token = '100pUKnkfLFklO7CZ8Y6PuoVxKSIO01AYkURGnUuPjg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}