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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9c2b6ab345ecaaf0643d79a17c94fa0473090565388bbfcd17c0e0987fdb2a44' 
  AND token = 'WfPPdjpMj8nRfvAK/EN1lmST1AhNyrKgcbyzVtB9NDA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}