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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '299c3afaf56a2f18fa3d3a784588d9c6eaef26b64bd3dd951c442eaf2702a446' 
  AND token = 'kgCSC4EZQWQUco52NAYdqDAU+I0NlB/uwh0eGQwwBNI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00061

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}