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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e0a80f7068794690673cfee4b201c738e6c5bbdbcd3f4e235f477c25a17b5891' 
  AND token = 'DzycstyXzPeL+bBDN+VHVFfhMq7E1uYz81cqvUg4Z0k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}