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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22331230f70c9e8369fa9b66c780eb9e8d91b3123168cd1fda0876d37afbcdc3' 
  AND token = 'IFDz4iSaLkhVutsnO3EtJMx5Q3WLQxbo8HTkOKpyMv0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}