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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50de6fd853693269af33c857e4f7ef2c7a4fba432c232294cf8caffc2c878f3f' 
  AND token = 'qyCr6Dicr++KtC8dZLMIsSFN1sAg+OkGuI7bLhwMYSE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}