SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1533d53e7180fee4e5eb69f5f4449db6a8ab62c355a913e2ad0fefe8c641a79f' 
  AND token = 'Xh4V0jwIzEBjPRaWFid2bkbiJtFkcSvo63TNdhiJdNc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}