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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b18f8ebc85eec3ce66d0c261b6d010e0a88a4432917465fc7e5f181ae9e9b193' 
  AND token = 'Pix9rBd80oyMt372BMq4/kurCZs2nzZofFHvJEEqkJ4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}