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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53c1ef10be7cc31f600b8eaa6868fa7deca7c7271a35c604654bf9e0f9a70d45' 
  AND token = 'pXJPRkjgTZH0/XXOFJxAeD0ZR/FRBBT8z9Csqy94ivw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}